منابع مشابه
Murine leukemia: a virus-induced autoimmune disease?
Thymocytes from mice carrying Moloney murine leukemia virus since birth are cytotoxic for normal syngeneic fibroblasts; they are much less cytotoxic for the same cells infected with this virus. The cytotoxic thymocytes appear to increase in number with age of the carrier mice and are present both during preleukemic and leukemic periods. These results suggest that lymphomas in carrier mice resul...
متن کاملPropylthiouracil-induced autoimmune disease
Hyperthyroidism is a condition characterized by excessive production of thyroid hormones. Propylthiouracil (PTU) is commonly used as first line drug in the management of hyperthyroidism. This is a case report of 24-year-old female, a known case of hyperthyroidism since 4 years, who came with a history of fever and myalgia since 3 days and dyspnea with coughing out of blood since 1 day. Patient ...
متن کاملEpstein-Barr Virus-induced Autoimmune Responses
During infectious mononucleosis, IgM autoantibodies are generated to a protein, p542, which contains a glycine-rich 28-mer epitope cross-reactive with the Epstein-Barr nuclear antigen-1 through Epstein-Barr nuclear antigen-l's glycine/ alanine repeat. In normal individuals it is uncommon to find IgG anti-p542, but among patients with progressive systemic sclerosis, systemic lupus erythematosus,...
متن کاملCD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.
Theiler's murine encephalomyelitis virus (TMEV) is a natural mouse pathogen which causes a lifelong persistent infection of the central nervous system (CNS) accompanied by T-cell-mediated myelin destruction leading to chronic, progressive hind limb paralysis. TMEV-induced demyelinating disease (TMEV-IDD) is considered to be a highly relevant animal model for the human autoimmune disease multipl...
متن کاملCan virus infections trigger autoimmune disease?
This review will examine various infectious parameters that could lead to enhancement or exacerbation of autoimmune disease. Multiple sclerosis (MS) will be the prototype human autoimmune disease detailed and experiments relating to the pathogenesis of MS will use data derived from an experimental animal model, experimental allergic encephalomyelitis (EAE). Other autoimmune diseases will be inc...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 1996
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(96)80019-7